Abstract: This guide is developed for anybody, who is interested in developing, adapting and implementing an evidence-based family skills training programme. The guide offers background information of scientific evidence and lists 12 key principles to keep in mind when using evidence-based family skills training programmes. In addition, the guide includes cultural adaptation guidelines to advice those who are planning to implement an existing programme, but have concerns about its suitability for their cultural context and language. The guide also provides practical advice on training of staff, recruitment of families, and finally on monitoring and evaluation.