Abstract: This evaluation report covers the period between 1997 and 1999. It is aimed at several types of reader: the Federal Office of Public Health (FOPH), decisionmakers, managers of institutions, etc. To facilitate access to more detailed information, footnotes and Appendices refer to the complete reports of the studies carried out during this phase of the evaluation. In addition, references are given at the end of each chapter. Priority in this report has been given to answers toevaluation questions. Chapter 1 (pp. 7-10) contains a brief recapitulation of the Confederation’s programme of public health measures to reduce drug-related problems (ProMeDro). The mandate and objectives of the overall evaluation are described in chapter 2 (pp.11-14). Chapter 3 (pp.15-42) covers the design & planning of the study. Chapter 4 (pp.43-82) presents an evaluation of the implementation and outcome of ProMeDro’s actions. Chapter 5 (pp. 83-90) deals with the study of the FOPH’s modes of delegation. Chapter6 (pp.91-98) presents the main results of a study of the FOPH’s partners. Chapter 7 (pp.99-108) describes and analyses health-related efforts carried out by the police among drug users. Chapter 8 (pp.109-120) covers the main epidemiological aspects of drug abuse in Switzerland, and compares them with some European data. Chapter 9 (pp.121-125), presents the general conclusions and the recommendations. Many projects, programmes and institutions are mentioned in this report: a lexicon of the main acronyms used can be found in appendix 5a. Definitions of the main categories used are presented in appendix 1a.