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Author |
Henke, Jura Inga; Goergen, Dagmar; Zheng, Yunfeng; Song, Yutong; Schüttler, Christian G.; Fehr, Carmen; Jünemann, Christiane; Niepmann, Michael |
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Title |
microRNA-122 stimulates translation of hepatitis C virus RNA |
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Journal Article |
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Year |
2008 |
Publication |
The EMBO Journal |
Abbreviated Journal |
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Volume |
27 |
Issue |
Advance Online Publication 24; 20.11.2008 |
Pages  |
1-11;3300 |
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Keywords |
hepatitis C; research |
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Abstract |
Hepatitis C virus (HCV) is a positive strand RNA virus that propagates primarily in the liver. We show here that the liver-specific microRNA-122 (miR-122), a member of a class of small cellular RNAs that mediate posttranscriptional gene regulation usually by repressing the translation of mRNAs through interaction with their 30-untranslated regions (UTRs), stimulates the translation of HCV. Sequestration of miR-122 in liver cell lines strongly reduces HCV translation, whereas addition of miR-122 stimulates HCV translation in liver cell lines as well as in the non-liver HeLa cells and in rabbit reticulocyte lysate. The stimulation is conferred by direct interaction of miR-122 with two target sites in the 50-UTR of the HCV genome. With a replication-defective NS5B polymerase mutant genome, we show that the translation stimulation is independent of viral RNA synthesis. miR-122 stimulates HCV translation by enhancing the association of ribosomes with the viral RNA at an early initiation stage. In conclusion, the liver-specific miR-122 may contribute to HCV liver tropism at the level of translation. |
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0261-4189 (Print); 1460-2075 (Electronic) |
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Call Number |
50-00831 |
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59668 |
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Author |
Wryobeck, John M.; Chermack, Stephen T.; Closser, Mary H.; Blow, Frederick C. |
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Title |
Using the addiction severity index to predict mental and medical health service utilization |
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Journal Article |
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Year |
2006 |
Publication |
Journal of addictive diseases |
Abbreviated Journal |
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Volume |
25 |
Issue |
4 |
Pages |
1-14 |
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Keywords |
Aod; AOD dependence; AOD use, abuse, and dependence; AOD user; AODR mental disorder; addiction; outpatient care; health care utilization; health care administration; mental health; statistical data; study; journal article |
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Call Number |
50-00621 |
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59650 |
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Author |
Farrell, Michael; Hall, Wayne |
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Title |
The Swiss heroin trials : testing alternative approaches : prescribed heroin is likely to have a limited role |
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Journal Article |
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Year |
1998 |
Publication |
British medical journal |
Abbreviated Journal |
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28.02.1998 |
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1 |
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Keywords |
treatment and maintenance; heroin; heroin-assisted treatment; methadone; commentary |
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Call Number |
50-00211 |
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59621 |
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Author |
Dole, Vincent P. |
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Title |
Übersetzung und Zusammenfassung : “what have we learned form three decades of methadone maintenance treatment?” |
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Journal Article |
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Year |
1994 |
Publication |
Drug and alcohol review |
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13 |
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1 |
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AOD use, abuse, and dependence; treatment and maintenance; methadone; commentary |
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German |
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Zusammenfassung von: 50-00126 |
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no |
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Call Number |
50-00127 |
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59613 |
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Author |
Schmidt, Rainer |
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Title |
Eingliederung und Teilhabe : der Hamburger Weg zur psychosozialen Betreuung Substituierter aus historischer Perspektive |
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Journal Article |
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2009 |
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Akzeptanzorientierte Drogenarbeit = Acceptance-oriented drug work |
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6 |
Issue |
20.01.2009 |
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1-5 |
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Keywords |
treatment and maintenance; outpatient care; psychosocial treatment method; history; Germany; Hamburg |
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1861-0110 |
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no |
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Call Number |
50-aaaad |
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59585 |
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| Permanent link to this record |
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Author |
Valleur, Marc; Velea, Dan |
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Title |
Les addictions sans drogue(s) |
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Journal Article |
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Year |
2002 |
Publication |
Revue Toxibase |
Abbreviated Journal |
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Volume |
11 |
Issue |
6; 06/2002 |
Pages |
1-15 |
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Keywords |
pathological gambling; prevention; disorder classification; intervention (persuasion to treatment); nonchemical addiction; eating disorder; behavioral and mental disorder |
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Abstract |
La définition du concept d’addiction apparaît de plus en plus difficile à cerner. Des toxicomanies à l’alcoolisme et au tabagisme, en passant par le jeu pathologique, les achats compulsifs, la sexualité et certains troubles du comportement… jusqu’à l’addiction, pourtant si peu virtuelle des cyberdépendants, on peut se demander quel est le point commun des addictions sans drogue et tout d’abord s’il existe. Ce questionnement est incontournable pour bâtir des stratégies de prévention et d’intervention médico-sociale adaptées. Il a également pour conséquence de penser les addictions en terme de conduite des sujets plutôt qu’une approche à partir des produits psychotropes. Ce thema de Toxibase propose d’entamer le débat à partir d’une vision conceptuelle des addictions sans drogue et d’une description nosographique et sociale de chacune d’entre elles. |
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French |
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1240-2494 |
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Call Number |
50-aah |
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59537 |
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Author |
Gachet, Stéphane |
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Title |
Argent: des joueurs au tapis |
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Journal Article |
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Year |
2002 |
Publication |
Uniscope : l’hebdomadaire de l’Université de Lausanne |
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3 |
Issue |
447; 24.04.2002 |
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1-2 |
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Keywords |
pathological gambling |
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French |
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Call Number |
50-aac |
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59532 |
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Author |
Vanderkloot, Pete |
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Title |
Methadone : medicine, harm reduction or social control |
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Journal Article |
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Year |
2001 |
Publication |
Harm Reduction Communication |
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11 |
Pages |
1-4 |
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Keywords |
chemical addiction; opioids in any form; methadone; drug; treatment and maintenance; drug substitution therapy; social control; harm reduction; bureaucracy |
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50-ah |
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59511 |
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Author |
various |
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Title |
Sucht = Addiction = Toxicomanie |
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Journal Article |
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Year |
2002 |
Publication |
Sozial und Präventivmedizin Médecine sociale et préventive Social and preventive medicine |
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Volume |
47 |
Issue |
4 |
Pages |
1-64 |
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Keywords |
addiction |
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German; French; English |
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0303-8408 |
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Dreisprachige Publikation Deutsch-Französisch-Englisch; publication trilingue allemand-français-anglais; trilingual publication German-French-English |
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Call Number |
12.00-015 |
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59476 |
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Author |
Zemlin, Uwe; Herder, Franz; Dornbusch, Peer |
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Title |
Wie wirkt sich die durch die Spargesetze bedingte Verkürzung der Behandlungsdauer in der stationären Rehabilitation Alkohol- und Medikamentenabhängiger auf den Behandlungserfolg von stationär Erstbehandelten und stationären Therapiewiederholern aus? Ergebnisse einer prospektiven Katamneseuntersuchung |
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Journal Article |
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Year |
1999 |
Publication |
Sucht aktuell : Zeitschrift des Fachverbandes Sucht e.V. |
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Volume |
6 |
Issue |
2 |
Pages |
1-18 |
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Keywords |
treatment and maintenance; inpatient care |
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German |
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ISSN |
1437-1650 |
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no |
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Call Number |
01.01-059 |
Serial |
59469 |
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| Permanent link to this record |
