Abstract: Naltrexone – an effective aid in the psychosocial rehabilitation process of former opiate dependent patients [Article in German] Ladewig D Naltrexon is an longterm opioid antagonist, which can be used in the psychosocial rehabilitation process of former dependents on opiates. It was established that there were less opiates used during the treatment with Naltrexon. The exclusive delivery of Naltrexon cannot protect from relapse and has to be completed with psychotherapeutic measures. Naltrexone. Kleber HD Naltrexone (Trexan R), a long acting, orally affective narcotic antagonist was approved by the Food & Drug Administration in November, 1984 for use as an adjunct in the treatment of Opioid Addiction. This research capsule will explore what is known about naltrexone, and the most appropriate ways of using the drug. Naltrexone treatment in a jail work-release program. Brahen LS, Henderson RK, Capone T, Kordal N. Inmates with a history of opiate addiction have traditionally been excluded from jail work-release programs because of their high likelihood of returning to drug use. In 1972, a new jail work-release program was begun in the Nassau County (New York) Jail, to which addicted inmates, who had formerly been excluded automatically, could request admission if they took the opiate blocking agent naltrexone. Inmates received naltrexone twice a week and had routine urine checks for drugs of abuse and an alcohol breath test when indicated. Psychological and vocational testing and weekly psychotherapy sessions were provided. For those no longer incarcerated, the adjacent hospital outpatient clinic was available for naltrexone treatment. Naltrexone has proved to be a completely effective opiate blocking agent with no major side effects in 691 patients over a 10-year period.