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Author |
Gianoulakis, C.; Béliveau, D.; Angeloglannl, P.; Meaney, H.; Thavundayll, J.; Tawar, V.; Dumas, M. |
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Title |
Differantial pituitary beta-endorphin and adrenal cortisol response to ethanol in individuals with high and low risk for future developement of alcoholism |
Type |
Journal Article |
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Year  |
1989 |
Publication |
Life Sciences |
Abbreviated Journal |
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Volume |
45 |
Issue |
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Pages |
1097-1109 |
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Keywords |
Aod; AOD use; AOD consumption; AOD associated consequences; AOD effects and AODR problems; AOD effects and consequences; AOD use initiation; AOD use pattern; alcohol; statistical data; study |
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Abstract |
The purpose of the present studies was to investigate the activity of the adrenal gland and the pituitary beta-endorphin system in individuals from families with a 3 generation history of alcoholism, High Risk group, or from families without history of alcoholism, Low Risk group. All subjects had a medical examination, a drinking behavior personal interview and the Michigan alcoholism Screening Test. Individuals with medical problems or excessive drinking were not included in the study. On the day of testing, a blood sample was taken at 9:00 a.m., then the subject drank a placebo drInk or an ethanol solution (0.5 g ethanol/kg B.Wt.). Additional blood samples were taken at 15, 45 and 120 minutes post-drink. Results indicated that individuals of the High Risk group had lower basal levels of beta-endorphin like immunoreactivity (beta-EPLlR) than individuals of the Low Risk group. The dose of 0.5 g ethanol/kg B.Wt. induced an increase in the plasma content of beta-EPLIR of the High Risk group, but not of the Low Risk group. In the Low Risk group ethanol did not induce an increase above the 9:00 a.m. levels, however, it attenuated the beta-endorphin decrease overtime, observed following the placebo drink. Analysis of beta-endorphin-like peptides in the plasma of the High Risk group, with Sephadex G-75 chromatography indicated that the major component of the plasma beta-EPLIR was beta-lipotropin. Plasma cortisol levels, following ethanol intake presented a small increase in the High Risk group but not in the Low Risk group. Both groups presented similar blood alcohol levels. The basal levels of immunoreactive cortisol and beta-endorphin in the plasma of individuals who were alcoholics, but had been abstinent for at least six months prior to testing were similar to the levels of the High Risk group. Thus there are differences both in the basel levels and In the response of the cortisol and the pituitary beta-endorphin system to an acute ethanol challenge between the two groups. |
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no |
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Call Number |
50-00240 |
Serial |
59626 |
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Author |
Naysmith, Peter |
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Title |
Laing on ecstasy |
Type |
Journal Article |
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Year |
1989 |
Publication |
International journal of drug policy |
Abbreviated Journal |
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Volume |
1 |
Issue |
3 |
Pages |
14-15 |
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Keywords |
addiction; AOD dependence; chemical addiction; ecstasy |
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ISSN |
0955-3959 |
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Call Number |
50-aaaaz |
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59607 |
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Author |
Friedman, Samuel R.; Sterk, Claire; Sufian, Meryl; Des Jarlais, Don C. |
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Title |
Will bleach decontaminate needles during cocaine binges in shooting galleries? |
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Journal Article |
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Year |
1989 |
Publication |
JAMA : the journal of the American Medical Association |
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Volume |
262 |
Issue |
11; 15.09.1989 |
Pages |
1467 |
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Keywords |
letter to the editor |
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ISSN |
0098-7484 |
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Call Number |
50-z |
Serial |
59503 |
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Author |
Kühn, Robert; Birett, Karl |
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Title |
Natriumhypochlorit Lösung |
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Book Chapter |
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Year |
1989 |
Publication |
Merkblätter Gefährliche Arbeitsstoffe |
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Keywords |
harm reduction |
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Ecomed-Storck |
Place of Publication |
Hamburg |
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German |
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no |
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Call Number |
50-02964 |
Serial |
59355 |
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Author |
various |
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Title |
The Drug Policy Letter : new ways of thinking about drugs : November / December 1989 |
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Journal |
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Year |
1989 |
Publication |
The Drug Policy Letter : new ways of thinking about drugs |
Abbreviated Journal |
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Volume |
1 |
Issue |
5; 11/1989 |
Pages |
11 |
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Keywords |
government and politics; international area |
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The Drug Policy Foundation |
Place of Publication |
Washington |
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English |
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no |
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Call Number |
13.02-015 |
Serial |
59172 |
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Author |
various |
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Title |
Menschenkenntnis : psychologische Zeitschrift für Ehe-, Erziehungs-, Berufs- und andere Lebensfragen 8/89 : aus dem Inhalt : im Vorfeld von Drogenmissbrauch : Auszüge aus Lebensläufen ehemals Drogenabhängiger |
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Journal |
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Year |
1989 |
Publication |
Menschenkenntnis : psychologische Zeitschrift für Ehe-, Erziehungs-, Berufs- und andere Lebensfragen |
Abbreviated Journal |
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Volume |
3 |
Issue |
8; 08/1989 |
Pages |
48 |
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Keywords |
addiction; addictive behavior |
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Verein zur Förderung der Psychologischen Menschenkenntnis |
Place of Publication |
Zürich |
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German |
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ISSN |
1013-798x |
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Call Number |
12.03-011 |
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59161 |
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Author |
Negrete, Juan C. |
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Title |
Menschenkenntnis : psychologische Zeitschrift für Ehe-, Erziehungs-, Berufs- und andere Lebensfragen 6/89 : was ist mit der Cannabis-Debatte geschehen? Ein Diskussionsbeitrag zum Cannabisproblem |
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Journal |
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Year |
1989 |
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Menschenkenntnis : psychologische Zeitschrift für Ehe-, Erziehungs-, Berufs- und andere Lebensfragen |
Abbreviated Journal |
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Volume |
3 |
Issue |
6; 06/1989 |
Pages |
40 |
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Keywords |
addiction; AOD dependence; chemical addiction; cannabis |
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Verein zur Förderung der Psychologischen Menschenkenntnis |
Place of Publication |
Zürich |
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German |
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1013-798x |
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Call Number |
12.01.02-020 |
Serial |
59154 |
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Author |
various |
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Title |
Menschenkenntnis : psychologische Zeitschrift für Ehe-, Erziehungs-, Berufs- und andere Lebensfragen 7/89 : psychologische und soziale Faktoren im Vorfeld von Drogenkonsum |
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Journal |
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Year |
1989 |
Publication |
Menschenkenntnis : psychologische Zeitschrift für Ehe-, Erziehungs-, Berufs- und andere Lebensfragen |
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3 |
Issue |
7; 07/1989 |
Pages |
40 |
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Keywords |
addiction |
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Verein zur Förderung der Psychologischen Menschenkenntnis |
Place of Publication |
Zürich |
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German |
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1013-798x |
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Call Number |
12.00-034 |
Serial |
59146 |
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Author |
Schmid, Adrian |
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Title |
Langenthals Fixer sollen “sauber” spritzen können (“Hot Shot”) |
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Newspaper Article |
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Year |
1989 |
Publication |
Berner Zeitung |
Abbreviated Journal |
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Issue |
23.09.1989 |
Pages |
21 |
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Keywords |
harm reduction |
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German |
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no |
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Call Number |
50-03257 |
Serial |
58327 |
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Author |
Beushausen, Gregor |
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Title |
Bürger rissen Spritzenautomaten aus der Wand |
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Newspaper Article |
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Year |
1989 |
Publication |
Frankfurter Rundschau |
Abbreviated Journal |
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Volume |
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Issue |
07.11.1989 |
Pages |
1 |
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Keywords |
harm reduction |
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Language |
German |
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Call Number |
50-03183 |
Serial |
58307 |
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