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anonymous |
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Title |
Zigaretten : schweigsamer Zeuge |
Type |
Magazine Article |
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Year |
1990 |
Publication |
Spiegel |
Abbreviated Journal |
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Volume |
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Issue |
18.05.1990 |
Pages |
1 |
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Keywords |
tobacco product; tobacco in any form; smoking; lobbying group; Germany |
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Abstract |
Geheimgehaltene Unterlagen beweisen: US-Tabakkonzeme verschleierten widrige Forschungsergebnisse und setzten Wissenschaftler unter Druck. |
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German |
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no |
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Call Number |
50-00554 |
Serial |
59030 |
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Author |
anonymous |
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Title |
CannaBioland will es wissen : Hanfbauer wehrt sich beim Bundesgericht gegen die Zerstörung seiner Pflanzen |
Type |
Newspaper Article |
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Year |
1990 |
Publication |
Tages-Anzeiger |
Abbreviated Journal |
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Volume |
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Issue |
22.08.1990 |
Pages |
27 |
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Keywords |
marijuana in any form; cannabis; plant and crop husbandry; jurisdiction; laws and regulations; Switzerland |
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German |
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no |
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Call Number |
50-00106 |
Serial |
57897 |
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| Permanent link to this record |
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Author |
Ansermot, Nicolas; Albayrak, Özgür; Schläpfer, Jürg; Crettol, Séverine; Croquette, Marina; Bourquin, Michel; Déglon, Jean-Jacques; Faouzi, Mohamed; Scherbaum, Norbert; Eap, Chin B. |
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Title |
Substitution of (R,S)-methadone by (R)-methadone : impact on QTc interval |
Type |
Journal Article |
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Year |
2010 |
Publication |
Archives of Internal Medicine |
Abbreviated Journal |
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Volume |
170 |
Issue |
6 |
Pages |
529-536 |
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Keywords |
methadone; opioids in any form; narcotic analgesics; drug substitution therapy; empirical study; statistical data |
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Abstract |
BACKGROUND: Methadone is administered as a chiral mixture of (R,S)-methadone. The opioid effect is mainly mediated by (R)-methadone, whereas (S)-methadone blocks the human ether-à-go-go-related gene (hERG) voltage-gated potassium channel more potently, which can cause drug-induced long QT syndrome, leading to potentially lethal ventricular tachyarrhythmias. METHODS: To investigate whether substitution of (R,S)-methadone by (R)-methadone could reduce the corrected QT (QTc) interval, (R,S)-methadone was replaced by (R)-methadone (half-dose) in 39 opioid-dependent patients receiving maintenance treatment for 14 days. (R)-methadone was then replaced by the initial dose of (R,S)-methadone for 14 days (n = 29). Trough (R)-methadone and (S)-methadone plasma levels and electrocardiogram measurements were taken. RESULTS: The Fridericia-corrected QT (QTcF) interval decreased when (R,S)-methadone was replaced by a half-dose of (R)-methadone; the median (interquartile range [IQR]) values were 423 (398-440) milliseconds (ms) and 412 (395-431) ms (P = .06) at days 0 and 14, respectively. Using a univariate mixed-effect linear model, the QTcF value decreased by a mean of -3.9 ms (95% confidence interval [CI], -7.7 to -0.2) per week (P = .04). The QTcF value increased when (R)-methadone was replaced by the initial dose of (R,S)-methadone for 14 days; median (IQR) values were 424 (398-436) ms and 424 (412-443) ms (P = .01) at days 14 and 28, respectively. The univariate model showed that the QTcF value increased by a mean of 4.7 ms (95% CI, 1.3-8.1) per week (P = .006). CONCLUSIONS: Substitution of (R,S)-methadone by (R)-methadone reduces the QTc interval value. A safer cardiac profile of (R)-methadone is in agreement with previous in vitro and pharmacogenetic studies. If the present results are confirmed by larger studies, (R)-methadone should be prescribed instead of (R,S)-methadone to reduce the risk of cardiac toxic effects and sudden death. |
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English |
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ISSN |
0003-9926 |
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Notes |
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Approved |
no |
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Call Number |
50-11821 |
Serial |
59945 |
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| Permanent link to this record |
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Author |
Antidoping Schweiz |
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Title |
Doping? : keine Ausreden – du bist für dein Handeln verantwortlich |
Type |
Book Whole |
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Year |
2010 |
Publication |
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Abbreviated Journal |
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Volume |
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Pages |
16 |
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Keywords |
prevention; amateur and professional sports; doping; specific AODU measurement and test; addiction; AOD dependence; chemical addiction |
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Abstract |
Diese Broschüre richtet sich an Nachwuchsathletinnen und -athleten, die sich über Dopingregeln und Dopingkontrollen informieren wollen. Angesprochen sind aber auch deren Begleitpersonen und allgemein am Sport Interessierte. Du findest hier alle wesentlichen Informationen zu Doping und Dopingkontrollen sowie zum Gebrauch von Arznei- und Nahrungsergänzungsmitteln. |
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Publisher |
Antidoping Schweiz |
Place of Publication |
Bern |
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Language |
German |
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Notes |
Aussi disponible en français: 50-11145; anche disponibile in italiano: 50-11146 |
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no |
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Call Number |
50-11144 |
Serial |
49731 |
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| Permanent link to this record |
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Author |
Antidoping Suisse |
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Title |
Dopage? : aucune excuse valable! Tu es responsable de tes actes |
Type |
Book Whole |
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Year |
2010 |
Publication |
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Abbreviated Journal |
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Pages |
16 |
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Keywords |
prevention; amateur and professional sports; doping; specific AODU measurement and test; addiction; AOD dependence; chemical addiction |
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Abstract |
Cette brochure est destinée aux jeunes sportifs qui souhaitent s’informer sur les règles en matière de dopage. Elle s’adresse également à leurs entraîneurs et de manière générale aux personnes qui s’intéressent au sport. Tu trouveras ici les informations essentielles en matière de contrôles antidopage; cette brochure aborde, par ailleurs, la question de l’utilisation des médicaments et des compléments alimentaires. |
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Publisher |
Antidoping Suisse |
Place of Publication |
Berne |
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Language |
French |
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Auch auf Deutsch vorhanden: 50-11144; anche disponibile in italiano: 50-11146 |
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no |
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Call Number |
50-11145 |
Serial |
49732 |
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| Permanent link to this record |
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Author |
Antidoping Svizzera |
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Title |
Doping? : niente scuse! Tu sei responsabile delle tue azioni |
Type |
Book Whole |
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Year |
2010 |
Publication |
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Abbreviated Journal |
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16 |
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Keywords |
prevention; amateur and professional sports; doping; specific AODU measurement and test; addiction; AOD dependence; chemical addiction |
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Abstract |
Questo opuscolo si rivolge a giovani sportive e sportivi che desiderano informarsi sulle regole e sui controlli antidoping. È rivolto anche al personale di supporto e a coloro che s’interessano di sport. Qui troverai tutte le informazioni essenziali sul doping, sui controlli antidoping e sull’uso di medicamenti e integratori alimentari. |
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Publisher |
Antidoping Svizzera |
Place of Publication |
Berna |
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Language |
Italian |
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Notes |
Auch auf Deutsch vorhanden: 50-11144; aussi disponible en français: 50-11145 |
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no |
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Call Number |
50-11146 |
Serial |
49733 |
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| Permanent link to this record |
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Author |
Antonoff, Laurent |
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Title |
Le plan lausannois pour combattre la toxicomanie : Après le rejet par les Lausannois d'un local d'injection en 2007, puis le retrait d'un préavis sur la toxicomanie par son auteur, Jean-Christophe Bourquin, le municipal a remis l'ouvrage sur le métier |
Type |
Newspaper Article |
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Year |
2010 |
Publication |
24 heures |
Abbreviated Journal |
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Volume |
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Issue |
12.05.2010 |
Pages |
2 |
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Keywords |
government and politics; harm reduction; contact center; vocational rehabilitation; stigma; public area; Lausanne |
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French |
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no |
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Call Number |
50-11279 |
Serial |
58757 |
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| Permanent link to this record |
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Author |
Aos, Steve; Miller, Marna; Drake, Elizabeth |
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Title |
Evidence-based public policy options to reduce future prison construction, criminal justice costs, and crime rates |
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Report |
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Year |
2006 |
Publication |
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Abbreviated Journal |
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43 |
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Keywords |
prevention; family therapy; criminality; prison; United States; Washington |
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Abstract |
Under current long-term forecasts, Washington State faces the need to construct several new prisons in the next two decades. Since new prisons are costly, the 2005 Washington Legislature directed the Washington State Institute for Public Policy to project whether there are “evidence-based” options that can: a) reduce the future need for prison beds, b) save money for state and local taxpayers, and c) contribute to lower crime rates. This report describes our findings and discusses how we conducted the analysis. We review evidence-based adult corrections, juvenile corrections, and prevention options and analyze the effects of alternative portfolios of these investments. |
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Washington State Institute for Public Policy (WSIPP) |
Place of Publication |
Washington |
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English |
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Call Number |
50-11768 |
Serial |
56447 |
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Author |
ap |
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Title |
Polizei zerschlägt Kokainring – im Magen in die Schweiz geschmuggelt |
Type |
Newspaper Article |
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Year |
2009 |
Publication |
Basler Zeitung |
Abbreviated Journal |
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Issue |
10.02.2009 |
Pages |
1 |
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Keywords |
cocaine; drug smuggling; drug trafficking; law enforcement; police; Switzerland |
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Abstract |
Grosser Fang der Polizei: Westafrikanische Drogenhändler sollen in den Jahren 2005 bis 2008 gut 15 Kilogramm Kokain in den Städten Lausanne, Genf und Biel abgesetzt haben. |
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German |
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Nicht mehr im Internet, 29.03.2016 |
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Call Number |
50-05007 |
Serial |
58383 |
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Author |
ap |
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Title |
Jugendalkoholismus nimmt massiv zu |
Type |
Newspaper Article |
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Year |
2009 |
Publication |
Tages-Anzeiger |
Abbreviated Journal |
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Issue |
06.11.2009 |
Pages |
5 |
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Keywords |
alcohol; alcohol intoxication; adolescent; monitoring; Switzerland |
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German |
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no |
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Call Number |
50-10733 |
Serial |
58668 |
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