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various |
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Title |
Syringe and Needle Exchange to Prevent HIV Infection |
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Journal Article |
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Year |
1994 |
Publication |
JAMA : the journal of the American Medical Association |
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Volume  |
271 |
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23; 15.06.1994 |
Pages |
1825-1827 |
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harm reduction |
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0098-7484 |
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Call Number |
50-03137 |
Serial |
59807 |
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Author |
Friedman, Samuel R.; Sterk, Claire; Sufian, Meryl; Des Jarlais, Don C. |
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Title |
Will bleach decontaminate needles during cocaine binges in shooting galleries? |
Type |
Journal Article |
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Year |
1989 |
Publication |
JAMA : the journal of the American Medical Association |
Abbreviated Journal |
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Volume |
262 |
Issue |
11; 15.09.1989 |
Pages |
1467 |
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Keywords |
letter to the editor |
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0098-7484 |
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50-z |
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59503 |
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Author |
Gröbli, Daniel |
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Title |
Colloque sur les politiques qualités dans le travail social : entre Davos et Porto Alegre |
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Journal Article |
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Year |
2001 |
Publication |
Avtes – communique |
Abbreviated Journal |
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Volume |
221 |
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Keywords |
quality control |
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French |
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Call Number |
50-03012 |
Serial |
59793 |
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Author |
Ansermot, Nicolas; Albayrak, Özgür; Schläpfer, Jürg; Crettol, Séverine; Croquette, Marina; Bourquin, Michel; Déglon, Jean-Jacques; Faouzi, Mohamed; Scherbaum, Norbert; Eap, Chin B. |
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Title |
Substitution of (R,S)-methadone by (R)-methadone : impact on QTc interval |
Type |
Journal Article |
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Year |
2010 |
Publication |
Archives of Internal Medicine |
Abbreviated Journal |
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Volume |
170 |
Issue |
6 |
Pages |
529-536 |
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Keywords |
methadone; opioids in any form; narcotic analgesics; drug substitution therapy; empirical study; statistical data |
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Abstract |
BACKGROUND: Methadone is administered as a chiral mixture of (R,S)-methadone. The opioid effect is mainly mediated by (R)-methadone, whereas (S)-methadone blocks the human ether-à-go-go-related gene (hERG) voltage-gated potassium channel more potently, which can cause drug-induced long QT syndrome, leading to potentially lethal ventricular tachyarrhythmias. METHODS: To investigate whether substitution of (R,S)-methadone by (R)-methadone could reduce the corrected QT (QTc) interval, (R,S)-methadone was replaced by (R)-methadone (half-dose) in 39 opioid-dependent patients receiving maintenance treatment for 14 days. (R)-methadone was then replaced by the initial dose of (R,S)-methadone for 14 days (n = 29). Trough (R)-methadone and (S)-methadone plasma levels and electrocardiogram measurements were taken. RESULTS: The Fridericia-corrected QT (QTcF) interval decreased when (R,S)-methadone was replaced by a half-dose of (R)-methadone; the median (interquartile range [IQR]) values were 423 (398-440) milliseconds (ms) and 412 (395-431) ms (P = .06) at days 0 and 14, respectively. Using a univariate mixed-effect linear model, the QTcF value decreased by a mean of -3.9 ms (95% confidence interval [CI], -7.7 to -0.2) per week (P = .04). The QTcF value increased when (R)-methadone was replaced by the initial dose of (R,S)-methadone for 14 days; median (IQR) values were 424 (398-436) ms and 424 (412-443) ms (P = .01) at days 14 and 28, respectively. The univariate model showed that the QTcF value increased by a mean of 4.7 ms (95% CI, 1.3-8.1) per week (P = .006). CONCLUSIONS: Substitution of (R,S)-methadone by (R)-methadone reduces the QTc interval value. A safer cardiac profile of (R)-methadone is in agreement with previous in vitro and pharmacogenetic studies. If the present results are confirmed by larger studies, (R)-methadone should be prescribed instead of (R,S)-methadone to reduce the risk of cardiac toxic effects and sudden death. |
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0003-9926 |
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Call Number |
50-11821 |
Serial |
59945 |
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Author |
Williamson, Nancy; Archibald, Chris; Van Vliet, Jon S. |
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Title |
Unexplained deaths among injection drug users : a case of probable clostridium myonecrosis |
Type |
Journal Article |
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Year |
2001 |
Publication |
Canadian Medical Association journal : CMAJ = Journal de l’Association médicale canadienne : JAMC |
Abbreviated Journal |
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Volume |
165 |
Issue |
5; 04.09.2001 |
Pages |
609-611 |
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Keywords |
intravenous drug user; AODR mortality; clostridium; gangrene; skin inflammation; primary health care; general practitioner; United Kingdom; Ireland |
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Abstract |
A series of unexplained deaths associated with soft-tissue inflammation and severe systemic sepsis was reported among injection drug users (IDUs) in the United Kingdom and the Republic of Ireland in 2000. Health Canada has identified one reported fatality in an IDU that matched the case definition. Although the cause of the epidemic in the UK and Ireland is not fully understood, contributing factors include injecting into muscle or beneath the skin, rather than directly into a vein, and the use of acid to dissolve the heroin. This single Canadian case is considered to be a sporadic event that occurs at a low background rate among IDUs. These cases serve to remind primary health care providers to be vigilant in cases of soft-tissue infection among IDUs and not to underestimate the potential severity of the situation. |
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ISSN |
0820-3946 |
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no |
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Call Number |
50-aj |
Serial |
59513 |
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Author |
Hawkins, J. David; Oesterle, Sabrina; Brown, Eric C.; Arthur, Michael W.; Abbott, Robert D.; Fagan, Abigail A.; Catalano, Richard F. |
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Title |
Results of a type 2 translational research trial to prevent adolescent drug use and delinquency : a test of Communities That Care |
Type |
Journal Article |
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Year |
2009 |
Publication |
Archives of pediatrics and adolescent medicine |
Abbreviated Journal |
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Volume |
163 |
Issue |
9; 09/2009 |
Pages |
789-798 |
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Keywords |
prevention; adolescent; criminality; United States |
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Abstract |
Objective To test whether the Communities That Care (CTC) prevention system reduces adolescent alcohol, tobacco, and other drug use and delinquent behavior communitywide. Design The Community Youth Development Study is the first randomized trial of CTC. Setting In 2003, 24 small towns in 7 states, matched within state, were randomly assigned to control or CTC conditions. Participants A panel of 4407 fifth-grade students was surveyed annually through eighth grade. Intervention A coalition of community stakeholders received training and technical assistance to install the CTC prevention system. They used epidemiological data to identify elevated risk factors and depressed protective factors in the community, and chose and implemented tested programs to address their community’s specific profile from a menu of effective programs for families, schools, and youths aged 10 to 14 years. Main Outcome Measures Incidence and prevalence of alcohol, tobacco, and other drug use and delinquent behavior by spring of grade 8. Results The incidences of alcohol, cigarette and smokeless tobacco initiation, and delinquent behavior were significantly lower in CTC than in control communities for students in grades 5 through 8. In grade 8, the prevalences of alcohol and smokeless tobacco use in the last 30 days, binge drinking in the last 2 weeks, and the number of different delinquent behaviors committed in the last year were significantly lower for students in CTC communities. Conclusion Using the CTC system to reduce health-risking behaviors in adolescents can significantly reduce these behaviors communitywide. |
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1072-4710 |
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Call Number |
50-10599 |
Serial |
59867 |
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Author |
Vogel, Marc; Petitjean, Sylvie; Borgwardt, Stefan; Wiesbeck, Gerhard A.; Walter, Marc |
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Title |
Therapie der Opioidabhängigkeit – ein Update |
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Journal Article |
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Year |
2010 |
Publication |
Schweizer Archiv für Neurologie und Psychiatrie |
Abbreviated Journal |
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Volume |
161 |
Issue |
1; 01/2010 |
Pages |
5-13 |
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Keywords |
treatment and maintenance; drug therapy; methadone; buprenorphine; psychosocial treatment method; AOD dependence; heroin; Switzerland |
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After the heroin-wave in Switzerland in the 1980s and 1990s and the establishment of successful maintenance therapies for harm reduction in many western countries, the first evidence-based guidelines for the treatment of opioid dependence appeared. Prevalence of heroin use in Switzerland has decreased subsequently in recent years with a large proportion of patients enrolled in maintenance therapies. In this review, pharmacological and psychosocial treatment strategies for opioid dependence are described and discussed with particular regard to current guidelines from European and American medical societies. |
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German |
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ISSN |
0258-7661 |
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Call Number |
50-11116 |
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59894 |
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Author |
Thorpe, Lorna E.; Ouellet, Lawrence J.; Hershow, Ronald; Bailey, Susan L.; Williams, Ian T.; Williamson, John; Monterroso, Edgar R.; Garfein, Richard S. |
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Title |
Risk of hepatitis C virus infection among young adult injection drug users who share injection equipment |
Type |
Journal Article |
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Year |
2002 |
Publication |
American journal of epidemiology |
Abbreviated Journal |
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Volume |
155 |
Issue |
7 |
Pages |
645-653 |
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Keywords |
risk assessment; intravenous drug user; young adult; needle sharing; viral hepatitis; hepatitis C; infection; United States; Chicago; study |
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Abstract |
Designing studies to examine hepatitis C virus (HCV) transmission via the shared use of drug injection paraphernalia other than syringes is difficult because of saturation levels of HCV infection in most samples of injection drug users (IDUs). The authors measured the incidence of HCV infection in a large cohort of young IDUs from Chicago, Illinois, and determined the risk of HCV seroconversion associated with specific forms of sharing injection paraphernalia. From 1997 to 1999, serum samples obtained from 702 IDUs aged 18–30 years were screened for HCV antibodies; prevalence was 27%. Seronegative participants were tested for HCV antibodies at baseline, at 6 months, and at 12 months. During 290 person-years of follow-up, 29 participants seroconverted (incidence: 10.0/100 person-years). The adjusted relative hazard of seroconversion, controlling for demographic and drug-use covariates, was highest for sharing “cookers” (relative hazard = 4.1, 95% confidence interval: 1.4, 11.8), followed by sharing cotton filters (relative hazard = 2.4, 95% confidence interval: 1.1, 5.0). Risks associated with syringe-sharing and sharing of rinse water were elevated but not significant. After adjustment for syringe-sharing, sharing cookers remained the strongest predictor of seroconversion (relative hazard = 3.5, 95% confidence interval: 1.3, 9.9). The authors conclude that sharing of injection equipment other than syringes may be an important cause of HCV transmission between IDUs. |
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0002-9262 |
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50-af |
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59509 |
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Author |
Fhima, Albert; Henrion, Roger; Lowenstein, William; Charpak, Yves |
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Title |
Suivi à 2 ans d'une cohorte de patients dépendants aux opiacés traités par buprénorophine haut dosage (Subutex) . Résultats de l'étude SPESUB |
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Journal Article |
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Year |
2001 |
Publication |
Annales de médecine interne |
Abbreviated Journal |
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152 |
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06/2001 |
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10 |
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treatment and maintenance; outpatient care |
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French |
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01.02-008 |
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59470 |
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Author |
B.S. |
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Title |
Grenzen setzen in 13 Sprachen |
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Journal Article |
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Year |
2004 |
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Bildung Schweiz : Sonderheft Computer und Internet |
Abbreviated Journal |
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Volume |
149 |
Issue |
11a; 11/2004 |
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42 |
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Keywords |
prevention; target group; adolescent; child; parent; education; school; migration; cultural integration; Suchtpräventionsstelle Zürcher Oberland (body) |
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Wo verschiedene Kulturen zusammentreffen, gibt es nicht nur Sprachprobleme. Davon erzählt der Film “Grenzenlos? – Aufwachsen in der Konsumgesellschaft”. Hervorragender Einstieg für einen Elternabend. |
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German |
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Call Number |
50-00789 |
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59666 |
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