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(2001). Schweizer PR- und Medienverzeichnis = Répertoire RP et médias suisses. Zürich: Edition Renteria.
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Ansermot, N., Albayrak, Ö., Schläpfer, J., Crettol, S., Croquette, M., Bourquin, M., et al. (2010). Substitution of (R,S)-methadone by (R)-methadone : impact on QTc interval. Archives of Internal Medicine, 170(6), 529–536.
Abstract: BACKGROUND: Methadone is administered as a chiral mixture of (R,S)-methadone. The opioid effect is mainly mediated by (R)-methadone, whereas (S)-methadone blocks the human ether-à-go-go-related gene (hERG) voltage-gated potassium channel more potently, which can cause drug-induced long QT syndrome, leading to potentially lethal ventricular tachyarrhythmias. METHODS: To investigate whether substitution of (R,S)-methadone by (R)-methadone could reduce the corrected QT (QTc) interval, (R,S)-methadone was replaced by (R)-methadone (half-dose) in 39 opioid-dependent patients receiving maintenance treatment for 14 days. (R)-methadone was then replaced by the initial dose of (R,S)-methadone for 14 days (n = 29). Trough (R)-methadone and (S)-methadone plasma levels and electrocardiogram measurements were taken. RESULTS: The Fridericia-corrected QT (QTcF) interval decreased when (R,S)-methadone was replaced by a half-dose of (R)-methadone; the median (interquartile range [IQR]) values were 423 (398-440) milliseconds (ms) and 412 (395-431) ms (P = .06) at days 0 and 14, respectively. Using a univariate mixed-effect linear model, the QTcF value decreased by a mean of -3.9 ms (95% confidence interval [CI], -7.7 to -0.2) per week (P = .04). The QTcF value increased when (R)-methadone was replaced by the initial dose of (R,S)-methadone for 14 days; median (IQR) values were 424 (398-436) ms and 424 (412-443) ms (P = .01) at days 14 and 28, respectively. The univariate model showed that the QTcF value increased by a mean of 4.7 ms (95% CI, 1.3-8.1) per week (P = .006). CONCLUSIONS: Substitution of (R,S)-methadone by (R)-methadone reduces the QTc interval value. A safer cardiac profile of (R)-methadone is in agreement with previous in vitro and pharmacogenetic studies. If the present results are confirmed by larger studies, (R)-methadone should be prescribed instead of (R,S)-methadone to reduce the risk of cardiac toxic effects and sudden death.
Keywords: methadone; opioids in any form; narcotic analgesics; drug substitution therapy; empirical study; statistical data
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Schön, A. (1998). Qualitätssicherung. In Qualität braucht Wissenschaft (pp. 525–533). Wien: Wiener Drogen Kommission.
Keywords: quality; quality control; organization; organizational structure; nonprofit; scientific model
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Gutzwiler, F., Jeanneret, O., Abelin, T., Ackermann-Liebrich, U., Paccaud, F., & Rougemont, A. (1996). Sozial- und Präventivmedizin Public Health (various, Ed.). Bern: H. Huber.
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Ott, R., & Biller-Andorno, N. (2013). La signification du neuroenhancement dans la pratique médicale. Bulletin des médecins suisses, 94(13-14; 27.03.2013), 504–506.
Abstract: Présentation des résultats de l’étude “La signification du neuroenhancement pour les praticiennes et praticiens des domaines de la psychiatrie/psychothérapie et de la médecine de premier recours”, qui a visé à mieux comprendre les expériences et la position des médecins confrontés à des demandes pour des produits de neuroenhancement dans leurs cabinets.
Keywords: research chemical; designer drug; treatment-provider-patient relations; physician; psychotherapy; psychiatric care; statistical data; survey
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Ott, R., & Biller-Andorno, N. (2013). Die Bedeutung des Neuroenhancements in der ärztlichen Praxis. Schweizerische Ärztezeitung, 94(13-14; 27.03.2013), 504–506.
Abstract: Vorgestellt werden Ergebnisse der Studie “Bedeutung des Neuroenhancements für praktizierende ÄrztInnen im Bereich Psychiatrie und Psychotherapie sowie im Bereich der Hausarztmedizin”. Diese Untersuchung zielte darauf ab, Erfahrungen und Einstellungen von Ärzten, die in ihrer Praxis mit der Nachfrage nach Neuroenhancement-Produkten konfrontiert werden, besser zu verstehen.
Keywords: research chemical; designer drug; treatment-provider-patient relations; physician; psychotherapy; psychiatric care; statistical data; survey
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Booth, R. E. (1994). Predictors of Unsafe Needle Practices : Injection Drug Users in Denver. Journal of acquired immune deficiency syndromes, 7, 504–508.
Abstract: To identify factors associated with unsafe needle hygiene, we studied 378 injection drug users (IDUs) in Denver, Colorado. The sample was drawn from neighborhoods with large concentrations of injectors and crack smokers. Respondents were questioned about their needle hygiene practices during the 30-day period prior to the interview. Unsafe needle hygiene, defined as injecting with previously used, nondisinfected needles, was reported by more than a third of those interviewed. Unsafe needle practices were associated with a number of factors, including heroin injection, perceived chance of getting AIDS, and lack of exposure to AIDS interventions in the community. The high percentage reporting unsafe needle practices within a 30-day interval points to the grave risk AIDS continues to pose for drug users. We conclude that the apparent success of exposure to AIDS intervention efforts in changing needle practices shows promise for prevention programs targeting drug injectors.
Keywords: harm reduction
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Hänni, C. (1998). Im Spannungsfeld zwischen Arzneimittel und Rauschgift : zur Geschichte der Betäubungsmittelgesetzgebung in der Schweiz (F. Ledermann, Ed.). Bern: Schweizerische Gesellschaft für Geschichte der Pharmazie (SGGP).
Keywords: government and politics; Switzerland
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Bundesamt für Gesundheit. (2000). Medienmitteilung: HIV-Infektionen und AIDS : Datenschutz-Massnahmen wurden verstärkt. Bulletin, (26; 26.06.2000), 498.
Keywords: health promotion; HIV infection; Aids
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Daeppen, J. - B. (2003). Screening and brief alcohol interventions in trauma centres. Swiss Medical Weekly, 133(37-38; 26.09.2003), 495–500.
Abstract: A third of all trauma beds are occupied by patients injured while under the influence of alcohol, yet trauma centres currently treat the injury and ignore the underlying alcohol problem. The incorporation of brief interventions to motivate patients to reduce alcohol intake has been associated with a reduction of their drinking and a resultant decrease in health care costs. While trauma centres are ideally situated for alcohol screening, interventions, and referral, the efficacy of such a program should be confirmed and the strategies for its optimal implementation in the routine practise of care should be further evaluated.
Keywords: alcohol; brief intervention; trauma center; injury; screening and diagnostic method for AOD use
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