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Author
Herrlin, Karin; Segerdahl, Märta; Gustafsson, Lars L.; Kalso, Eija
Title
Methadone, ciprofloxacin, and adverse drug reactions
Type
Journal Article
Year
2000
Publication
The Lancet
Abbreviated Journal
Volume
356
Issue
9247; 16.12.2000
Pages
2069-2070
Keywords
treatment and maintenance; methadone; ciprofloxacin; adverse drug effect
Abstract
Ciprofloxacin, given to a patient successfully treated with methadone for more than 6 years, caused profound sedation, confusion, and respiratory depression. We suggest that this was caused by ciprofloxacin inhibition of CYP1A2 and CYP3A4 activity, two of the cytochrome p450 isozymes involved in the metabolism of methadone.
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English
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0140-6736
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no
Call Number
50-03421
Serial
59836
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