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Meyer, R. E. (1996). The disease called addiction : emerging evidence in a 200-year debate. The Lancet, 347, 162–166.
Keywords: addiction; history
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Seivewright, N. A., & Greenwood, J. (1996). What is important in drug misuse treatment? The Lancet, 347(10.02.1996), 373–376.
Keywords: treatment and maintenance; methadone maintenance; harm reduction; HIV infection; detoxification; drug substitution therapy; United Kingdom
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Herrlin, K., Segerdahl, M., Gustafsson, L. L., & Kalso, E. (2000). Methadone, ciprofloxacin, and adverse drug reactions . The Lancet, 356(9247; 16.12.2000), 2069–2070.
Abstract: Ciprofloxacin, given to a patient successfully treated with methadone for more than 6 years, caused profound sedation, confusion, and respiratory depression. We suggest that this was caused by ciprofloxacin inhibition of CYP1A2 and CYP3A4 activity, two of the cytochrome p450 isozymes involved in the metabolism of methadone.
Keywords: treatment and maintenance; methadone; ciprofloxacin; adverse drug effect
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various. (1992). Needlestick injury (Letters to the Editor). The Lancet, 340(07.11.1992), 1166–1167.
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Nixon, A. D., Law, R., Officer, J. A., Cleland, J. F., & Goldwater, P. N. (1986). Methods and devices : simple device to prevent accidental needle-prick injuries. The Lancet, (19.04.1986), 888–889.
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McCarthy, M. (1994). LA law and clean needles. The Lancet, 344(8925; 17.09.1994), 810.
Abstract: Reports that Los Angeles, California Mayor Richard J. Riordan has declared a local state of emergency to the spread of AIDS and HIV infection. State crackdown on the distribution of clean needles to drug users; Riordan’s support for responsible needle-exchange programs.
Keywords: harm reduction
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Donoghoe, M. C., & Power, R. (1993). Household bleach as disinfectant for use by injecting drug users. The Lancet, 341(26.06.1993), 1658.
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Bousingen, D. D. de. (2001). Drug firm compensates patients for suspected hepatitis B vaccine failure. The Lancet, 357(19.05.2001), 1598.
Abstract: A French appeal court has ordered GlaxoSmithKline (GSK) to pay US$6686 and US$10 697 in compensation to two women with multiple sclerosis who claim the chronic disease was caused by a hepatitis B vaccine (Engerix B) manufactured by the pharmaceutical company.
Keywords: health promotion; viral hepatitis; hepatitis B
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McElhatton, P. R., Bateman, D. N., Evans, C., Pughe, K. R., & Thomas, S. H. L. (1999). Congenital anomalies after prenatal ecstasy exposure. The Lancet, 354(9188; 23.10.1999), 1441–1442.
Abstract: Prospective follow-up of 136 babies exposed to ecstasy in utero indicated that the drug may be associated with a significantly increased risk of congenital defects (15·4% [95% CI 8·2—25·4]). Cardiovascular anomalies (26 per 1000 livebirths [3·0—9·0]) and musculoskeletal anomalies (38 per 1000 [8·0—109·0]) were predominant.
Keywords: health promotion; addiction; AOD dependence; chemical addiction; ecstasy
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Rehm, J., Gschwend, P., Steffen, T., Gutzwiller, F., Dobler-Mikola, A., & Uchtenhagen, A. (2001). Feasibility, safety, and efficacy of injectable heroin prescription for refractory opioid addicts : a follow-up study. The Lancet, 358(27.10.2001), 1417–1420.
Abstract: Background : Heroin-assisted substitution treatment for severely opioid-dependent drug users has been available in Switzerland since 1994. Our aim was to ascertain the feasibility, safety, and efficacy of this treatment. Methods : We did a cohort study in 21 community outpatient treatment centres. We assessed 1969 opioid-dependent drug users, who began heroin-assisted substitution treatment between January, 1994, and December, 2000, to ascertain admission and discharge patterns, and patient characteristics. We also followed up a subset of 237 patients who began treatment between Jan 1, 1994, and March 31, 1995, and who stayed with the programme for at least 18 months. We used questionnaires, interviews, and medical examinations done at entry and after 6, 12, and 18 months to assess somatic and mental health, social integration, and treatment outcomes. Findings : More than 70% (1378) of patients remained in treatment for more than a year. Treatment showed positive effects with respect to health and social outcomes. A long stay in treatment was related to a higher chance of starting abstinence-oriented therapy than a short stay. Interpretation : Heroin-assisted substitution treatment might be an effective option for chronically addicted patients for whom other treatments have failed.
Keywords: AOD dependence; opioids in any form; heroin; heroin-assisted treatment; treatment and maintenance; study; statistical data; Switzerland
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