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| Author | Herrlin, Karin; Segerdahl, Märta; Gustafsson, Lars L.; Kalso, Eija | ||||
| Title | Methadone, ciprofloxacin, and adverse drug reactions | Type | Journal Article | ||
| Year | 2000 | Publication | The Lancet | Abbreviated Journal | |
| Volume | 356 | Issue | 9247; 16.12.2000 | Pages  |
2069-2070 |
| Keywords | treatment and maintenance; methadone; ciprofloxacin; adverse drug effect | ||||
| Abstract | Ciprofloxacin, given to a patient successfully treated with methadone for more than 6 years, caused profound sedation, confusion, and respiratory depression. We suggest that this was caused by ciprofloxacin inhibition of CYP1A2 and CYP3A4 activity, two of the cytochrome p450 isozymes involved in the metabolism of methadone. | ||||
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| Corporate Author | Thesis | ||||
| Publisher | Place of Publication | Editor | |||
| Language | English | Summary Language | Original Title | ||
| Series Editor | Series Title | Abbreviated Series Title | |||
| Series Volume | Series Issue | Edition | |||
| ISSN | 0140-6736 | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | Approved | no | |||
| Call Number | 50-03421 | Serial | 59836 | ||
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