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Author (up) Herrlin, Karin; Segerdahl, Märta; Gustafsson, Lars L.; Kalso, Eija url 
  Title Methadone, ciprofloxacin, and adverse drug reactions   Type Journal Article
  Year 2000 Publication The Lancet Abbreviated Journal  
  Volume 356 Issue 9247; 16.12.2000 Pages 2069-2070  
  Keywords treatment and maintenance; methadone; ciprofloxacin; adverse drug effect  
  Abstract Ciprofloxacin, given to a patient successfully treated with methadone for more than 6 years, caused profound sedation, confusion, and respiratory depression. We suggest that this was caused by ciprofloxacin inhibition of CYP1A2 and CYP3A4 activity, two of the cytochrome p450 isozymes involved in the metabolism of methadone.  
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  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0140-6736 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number 50-03421 Serial 59836  
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