| |
Records |
Links |
|
Author |
Abteilung Koordination Drogenfragen |
|
| |
Title |
Dokumentation Ecstasy : rechtliche Aspekte, medizinisch-psychologische Aspekte, kulturelle Aspekte, Präventionsaspekte |
Type |
Report |
| |
Year |
1995 |
Publication |
|
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
|
Pages |
100 |
|
| |
Keywords  |
addiction; AOD dependence; chemical addiction; ecstasy |
|
| |
Abstract |
|
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Justizdepartement des Kantons Basel-Stadt, Abteilung Koordination Drogenfragen (AKOD) |
Place of Publication |
Basel |
Editor |
|
|
| |
Language |
German |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
50-03294 |
Serial |
50639 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Poethko-Müller, C. |
|
| |
Title |
Ecstasy – neue pharmakologische und epidemiologische Erkenntnisse und deren praktische Bedeutung |
Type |
Journal Article |
| |
Year |
1999 |
Publication |
Bundesgesundheitsblatt : Gesundheitsforschung : Gesundheitsschutz |
Abbreviated Journal |
|
|
| |
Volume |
42 |
Issue |
|
Pages |
187-195 |
|
| |
Keywords |
addiction; AOD dependence; chemical addiction; ecstasy |
|
| |
Abstract |
Ecstasy ist ein Sammelbegriff für verschiedene Methylendioxyamphetamine mit antriebssteigernder und halluzinogener Wirkung, die darüber hinaus eine sogenannte „entaktogene” Wirkung aufweisen. Der Begriff „entaktogen” wird als „im Inneren ein Gefühl erzeugen” oder „Herstellen einer inneren Berührung”übersetzt und charakterisiert die Wirkung psychoaktiver Stoffe, die unbewußte Gefühle und Erfahrungen wieder zugänglich machen und die Selbstreflexion fördern. Bei 3,4 Methylendioxymethamphetamin (MDMA) als Hauptvertreter dieser Gruppe steht diese entaktogene Wirkung im Vordergrund des erstrebten Rausches. Darüber hinaus erzeugt MDMA neben den auch vorhandenen antriebssteigernden und euphorisierenden Wirkungen ein Gefühl der großen Nähe zu anderen Menschen. Negative psychotrope Wirkungen können den akuten Rausch überdauern und werden vor allem in Form von depressiver Verstimmung und Angst erlebt. Ecstasy ist keine neue Substanz. Neu ist jedoch das Ausmaß und die Geschwindigkeit, mit der sich Ecstasy – gekoppelt an die Verbreitung der Techno-Party-Szene – weltweit durchgesetzt hat. Epidemiologische Untersuchungen der letzten zwei Jahre vermitteln Einblicke, die über die eindrücklichen Steigerungsraten der Bundeskriminalstatistiken (Sicherstellungsmengen; Anteil an den erstauffälligen Konsumenten) hinausgehen. Die aus Repräsentativerhebungen und Erhebungen in der Technoszene ermittelte Lebenszeitprävalenz für Ecstasy bestätigen den intensiven Gebrauch vor allem in dieser Szene als sog. „Freizeitdroge”. Darüber hinaus zeichnet sich jedoch die Existenz einer Konsumentengruppe mit exzessiven Gebrauchsmustern und psychischer Abhängigkeit ab. Für diese Gruppe wird ein erhebliches Risiko hinsichtlich medizinischer oder psychiatrischer Komplikationen angenommen. Diese Komplikationen lassen sich auf zentrale und periphere serotonerge Wirkungen von Ecstasy zurückführen bzw. durch die neurotoxischen Wirkungen von Ecstasy erklären. Die Quote psychisch abhängiger Ecstasy-Konsumenten ist überraschend hoch. Die möglichen neurotoxischen Wirkungen sind eventuell irreversibel. Die Risiken und die Ausbreitungsgeschwindigkeit von Ecstasy zeigen die Notwendigkeit geeigneter primär- und sekundärpräventiver Maßnahmen, die durch das herkömmliche Drogenhelfersystem bislang nur unzureichend geleistet werden konnten. |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
German |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
50-03293 |
Serial |
59830 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Fitzgerald, John L. |
|
| |
Title |
MDMA and Harm |
Type |
Journal Article |
| |
Year |
1991 |
Publication |
International journal of drug policy |
Abbreviated Journal |
|
|
| |
Volume |
2 |
Issue |
4 |
Pages |
22-24 |
|
| |
Keywords |
addiction; AOD dependence; chemical addiction; ecstasy |
|
| |
Abstract |
|
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
50-03286 |
Serial |
59829 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Buchert, Ralph; Thomasius, Rainer; Nebeling, Bruno; Petersen, Kay; Obrocki, Jost; Jenicke, Lars; Wilke, Florian; Wartberg, Lutz; Zapletalova, Pavlina; Clausen, Malte |
|
| |
Title |
Long-Term Effects of “Ecstasy” : Use on Serotonin Transporters of the Brain Investigated by PET |
Type |
Journal Article |
| |
Year |
2003 |
Publication |
Journal of nuclear medicine |
Abbreviated Journal |
|
|
| |
Volume |
44 |
Issue |
3 |
Pages |
375-384 |
|
| |
Keywords |
addiction; AOD dependence; chemical addiction; ecstasy |
|
| |
Abstract |
Alterations of the serotonergic system due to ecstasy consumption have been extensively documented in recent literature. However, reversibility of these neurotoxic effects still remains unclear. To address this question, PET was performed using the serotonin transporter (SERT) ligand 11C-(+)-McN5652 in a total of 117 subjects subdivided into 4 groups: actual ecstasy users (n = 30), former ecstasy users (n = 29), drug-naive control subjects (n = 29), and subjects with abuse of psychoactive agents other than ecstasy (n = 29). Methods: About 500 MBq 11C-(+)-McN5652 were injected intravenously. Thirty-five scans were acquired according to a dynamic scan protocol of 90 min using a full-ring whole-body PET system. Transaxial slices were reconstructed using an iterative method. Individual brains were transformed to a template defined earlier. Distribution volume ratios (DVRs) were derived by application of a reference tissue approach for reversible binding. Gray matter of the cerebellum served as reference. SERT-rich brain regions—mesencephalon, putamen, caudate, and thalamus—were selected for the evaluation of SERT availability using volumes of interest predefined in the template. Results: Compared with drug-naive control subjects, the DVR in actual ecstasy users was significantly reduced in the mesencephalon (P = 0.004) and the thalamus (P = 0.044). The DVR in former ecstasy users was very close to the DVR in drug-naive control subjects in all brain regions. The DVR in polydrug users was slightly higher than that in the drug-naive control subjects in all SERT-rich regions (not statistically significant). Conclusion: Our findings further support the hypothesis of ecstasy-induced protracted alterations of the SERT. In addition, they might indicate reversibility of the availability of SERT as measured by PET. However, this does not imply full reversibility of the neurotoxic effects. |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
50-03284 |
Serial |
59828 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Naysmith, Peter |
|
| |
Title |
Laing on ecstasy |
Type |
Journal Article |
| |
Year |
1989 |
Publication |
International journal of drug policy |
Abbreviated Journal |
|
|
| |
Volume |
1 |
Issue |
3 |
Pages |
14-15 |
|
| |
Keywords |
addiction; AOD dependence; chemical addiction; ecstasy |
|
| |
Abstract |
|
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0955-3959 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
50-aaaaz |
Serial |
59607 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Angel, Pierre; Landry, Michel |
|
| |
Title |
Ecstasy |
Type |
Journal |
| |
Year |
2000 |
Publication |
Psychotropes : revue internationale des toxicomanies |
Abbreviated Journal |
|
|
| |
Volume |
6 |
Issue |
2 |
Pages |
171 |
|
| |
Keywords |
addiction; AOD dependence; chemical addiction; ecstasy |
|
| |
Abstract |
|
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
De Boeck |
Place of Publication |
Paris |
Editor |
|
|
| |
Language |
French |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1245-2092; Isbn : 2-8041-3401-6 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
12.01.03-007 |
Serial |
59156 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Connor, Steve |
|
| |
Title |
Memory is damaged by ecstasy |
Type |
Newspaper Article |
| |
Year |
1998 |
Publication |
Independent |
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
21.12.1998 |
Pages |
|
|
| |
Keywords |
addiction; AOD dependence; chemical addiction; ecstasy |
|
| |
Abstract |
|
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
50-03285 |
Serial |
58333 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Goodchild, Sophie |
|
| |
Title |
Herbal 'antidote' leads to dangerous ecstasy boom |
Type |
Newspaper Article |
| |
Year |
1999 |
Publication |
The Independent |
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
01.08.1999 |
Pages |
1 |
|
| |
Keywords |
addiction; AOD dependence; chemical addiction; ecstasy |
|
| |
Abstract |
|
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
50-03287 |
Serial |
58334 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Bailly, Daniel; Binder, Philippe; Choquet, Marie; Facy, Françoise; Feger, Jean; Ferrand, Isabelle; Hervé, Denis; Jouglard, Jacqueline; Kintz, Pascal; Kokoreff, Michel; Mignon, Patrick; Simon, Hervé |
|
| |
Title |
Ecstasy : des données biologiques et cliniques aux contextes d'usage |
Type |
Book Whole |
| |
Year |
1997 |
Publication |
|
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
|
Pages |
243, annexes |
|
| |
Keywords |
addiction; AOD dependence; chemical addiction; ecstasy |
|
| |
Abstract |
L’ecstasy (MDMA) fait partie d’un ensemble de drogues de synthèse, produits psychostimulants utilisés par de jeunes adultes dans le cadre d’un certain mode de vie. La rencontre avec un courant musical semble bien avoir décuplé sa diffusion dans les milieux de la jeunesse branchée, jusqu’à en faire un véritable « phénomène » qui est l’objet de préocupation pour les différents acteurs de prévention. Analyser et valider les connaissances scientifiques disponibles sur le plan mondial représente une étape préalable indispensable à la mise en place d’actions de prévention. Il s’agit de présenter les caractéristiques du produit, de préciser les risques de sa consommation et les motivations et contexte de son usage, afin de donner des moyens pour combattre et/ou gérer son utilisation. Cependant, connaître les déterminants psychologiques qui induisent la consommation d’un tel produit est un autre aspect du problème, tout aussi important pour la prévention primaire, et qui n’a pas été abordé dans ce travail. Dire que l’on ne sait rien aujourd’hui sur les risques de la consommation d’ecstasy serait faux, mais dire que l’on sait tout serait tout aussi faux. Les très nombreux travaux réalisés chez l’animal ont permis de comprendre le mécanisme d’action de la molécule de MDMA sur le système nerveux central. Démontrer chez l’homme, comme cela est fait chez le singe, l’atteinte neuronale irréversible demeure un enjeu capital, puisque peu de drogues peuvent entraîner de tels effets. L’analyse approfondie des données cliniques publiées permet de conclure à l’imputabilité de la molécule de MDMA dans l’apparition chez l’utilisateur d’un certain nombre d’effets toxiques à expression périphérique, en particulier lorsque l’analyse toxicologique confirme la présence exclusive de MDMA dans le sang ou les urines. Le syndrome d’hyperthermie, complication grave et immédiate, est dans ce cadre bien documenté, de même que d’autres pathologies comme les hépatites qui peuvent apparaître après plusieurs prises. En l’absence d’une mise en évidence directe de lésions neuronales, l’imputabilité très probable de la MDMA dans l’apparition de troubles psychiatriques et cognitifs ne peut être déduite que de l’observation de leur fréquence chez des consommateurs réguliers d’ecstasy. Si les effets psychotropes recherchés sont souvent dépendants du contexte d’usage, le plus souvent festif, les effets délétères semblent bien répondre à des susceptiblilités individuelles dont les bases biologiques restent encore à définir. Savoir si la MDMA peut induire chez le consommateur une dépendance est également une question essentielle, que jusqu’à maintenant les travaux réalisés chez le rat n’ont pas permis de résoudre, tout en apportant la preuve des potentialités toxicomanogènes de la molécule. Même si une polyconsommation est très souvent évoquée dans les travaux, il se dégage néanmoins un profil sociologique des consommateurs qui les différencie des usagers d’autres drogues comme l’héroïne... |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Institut national de la santé et de la recherche médicale (INSERM) |
Place of Publication |
Paris |
Editor |
Etiemble, Jeanne; Prigent, Marie-José; Chollet-Przednowed, Emmanuelle; Grellier, Chantale; Bizard, Jean-Baptiste |
|
| |
Language |
French |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
50-10623 |
Serial |
54490 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
various |
|
| |
Title |
The big blue book of dance drugs |
Type |
Book Whole |
| |
Year |
1990 |
Publication |
|
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
|
Pages |
16 |
|
| |
Keywords |
addiction; AOD dependence; chemical addiction; ecstasy |
|
| |
Abstract |
|
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Lifeline |
Place of Publication |
Manchester |
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
12.01.03-001 |
Serial |
54738 |
|
| Permanent link to this record |
